Graviola, soursop is a 5-6 m small tree with dark green leaves and large edible fruits originating from South America. For centuries, South America indigenous people have used all parts of the Graviola tree as a natural medicine for various illnesses.

According to history, after Columbus discovered the Americas, this plant was bought to the Asian continent. The tree grows well in all of Indonesia and the Dutch loved the delicious sour fruit, calling it "Zuurzak".

Many bioactive compounds and phytochemicals have been found in Graviola as scientists have studied its properties since the 1940's. But in 1976, research done by the National Cancer Institute, USA, found that the Graviola leaves contain a novel group of phytochemicals called Annonaceous Acetogenins, these have demonstrated significant anti-tumorous and anti-cancerous properties, without harming healthy cells by decreasing the energy level of the cancer cells, an ATP inhibitor.

The traditional way of administering the plant is boiling the Graviola (sirsak) leaves with water. However a more modern and effective method is using Graviola leaf extract, Grav-X® to obtain a precise and safe dosage form.

Phytochemindo has developed Grav-X®, a proprietary branded standardized plant extract with a high content of acetogenins drom selected Graviola leaves. Being a native plant of Indonesia Grav-X® is manufactured using selected raw materials from native Indonesian trees in our WHO GMP certified extraction plant.

Various in vitro and in vivo studies by the Purdue University USA, Catholic University of South Korea as well as Japanese and Indonesian researchers, have found that Annonaceous Acetogenins contain annonacin and 82 types of acetogenins. These acetogenins can destroy malignant cells in breast, skin, lung, colon, prostate and other cancers.

Besides being a potential cancer remedy, several studies have demonstrated other health benefits of the Graviola leaf extract, including :
  • Antibacterial
  • Antiviral and anti fungal properties
  • Prevention of hemorrhoids
  • Lowering of blood pressure
  • and on-going studies are being done into suppressing HIV infections (anti AIDS)
The key active substances of GRAV-X® are :
  • Annonaceous Acetogenins
  • Alkaloids
  • Lactones
  • Pharmaceutical -- Graviola is best known for its anti-cancer properties. Researchers are very enthusiastic about Graviola being an alternative medicine to be used as supportive therapy for cancers, such as breast cancer, prostate cancer, liver cancer, lung cancer, pancreatic cancer, and lymphoma. It is one of the most studied properties of the tree and so far it has shown positive results. Graviola also potential as alternative treatment to treat diabetes, high blood pressure and studies of Graviola others benefits still being developed.